Organophosphorus compounds as chemical warfare agents: a review

Gene-delivered butyrylcholinesterase is prophylactic against the toxicity of chemical warfare nerve agents and organophosphorus compounds.

Gene delivery using an adenoviral system has been effective in introducing therapeutic proteins in vitro and in vivo. This study tested the feasibility of using adenovirus to deliver clinically relevant amounts of butyrylcholinesterase (BChE), a proven bioscavenger of nerve agents. The adenovirus construct expressed full-length mouse BChE. Mice were injected with a single dose of adenovirus (1....

Chemical Warfare Agents

Chemical Compounds as Carcinogenic Agents

A review of the progress made in the study of the carcinogenic properties of chemical compounds, incorporating literature published during the triennial period between the First and Second International Cancer Congresses, was presented to the Second International Congress in Brussels, in September 1936, and was subsequently reprinted with an addendum covering most of the literature published up...

Enzyme-based Detoxification of Organophosphorus Neurotoxic Pesticides and Chemical Warfare Agents

Enzyme-based Detoxification of Organophosphorus Neurotoxic Pesticides and Chemical Warfare Agents. (December 2007) Rory James Kern, B.S., Texas A&M University Chair of Advisory Committee: Dr. James Wild There are some 15,000 known organophosphorus chemicals. Some of these OP’s, including VX and paraoxon, demonstrate an acute neurotoxicity due to the inhibition of cholinergic enzymes. Organophos...

FETAL DEATHS AND PARENTAL EXPOSURE TO CHEMICAL WARFARE AGENTS

In the present work we studied the incidence of fetal deaths among conceptions whose fathers or both parents were survivors of chemical warfare attacks by Iraq. We showed that there was significant correlation between frequency of fetal deaths among conceptions which eventuated after exposure of the parents to gas bombs compared to the frequency of fetal deaths among the control group. Thi...